In 1908, after receiving approval from Pope Cyril V, Marcus Simaika Pasha started building the Coptic Museum and it was inaugurated it on 14 March 1910.
The museum is located in Old Cairo ( Religious Complex), within the walls of the Roman fortress of Babylon, surrounded by some of the oldest and most important churches in Egypt, like the Church of Virgin Mary, the Hanging Church and the Church of Abu Serga, in addition to the oldest Jewish synagogue(Ben Ezra), which dates back to the 9th century AD, and just a few minutes' walk from is Amr Ibn Al-Aas Mosque.